A community resource
Two copies of APOE4 may be a genetic form of Alzheimer’s disease.
Evidence, data resources, papers, trials and drugs on APOE ε4 homozygosity, gathered in one place for the community.
ε4/ε4About 2–3% of people
Gene and evidence
Three forms of APOE, one amino acid apart, and what two copies of ε4 do to timing, amyloid and blood vessels.
Resources
Cohorts and repositories with ε4/ε4 data, and how to access them.
Key papers
The studies that define what we know, grouped by topic.
Clinical trials
Trials in ε4/ε4 carriers and trials that report results by genotype.
Drugs
Approved and investigational treatments, and what they mean for ε4/ε4.
Newsletter
Research updates on APOE4 in your inbox.